ea0037gp.15.05 | Diabetes and obesity – basic | ECE2015
O'Harte Finbarr P M
, Ng Ming T
, Conlon J Michael
, Flatt Peter R
Recent acute in vivo studies have shown that structural modifications of dogfish glucagon improves peptide stability and these analogues can act as dual agonists at both glucagon and GLP-1 receptors. Here, we compared the effects of chronic (51 days) twice daily administration of [D-Ala2]dogfish glucagon (Pep-N) and [D-Ala2]dogfish glucagon-exendin-4(3139) construct (Pep-C), exendin-4(139) or saline treat...